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A B C D E F G H I J K L M N O P R S T U V W Y Z
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Zuniga-Hertz etal 2023

Zuniga-Hertz, Juan P. (2023): Meditation-induced bloodborne factors as an adjuvant treatment to COVID-19 disease. Juan P. Zuniga-Hertz, Ramamurthy Chitteti, Joe Dispenza, Raphael Cuomo, Jacqueline A. Bonds, Elena L. Kopp, Sierra Simpson, Jonathan Okerblom, Svetlana Maurya, Brinda K. Rana, Atsushi Miyonahara, Ingrid R. Niesman, Jacqueline Maree, Gianna Belza, Hillari D. Hamilton, Carla Stanton, David J. Gonzalez, Michelle A. Poirier, Tobias Moeller-Bertram and Hemal H. Patel. In: Brain, Behavior, & Immunity – Health. 32.2023

Abstract

The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. Management of the pandemic has relied mainly on SARS-CoV-2 vaccines, while alternative approaches such as meditation, shown to improve immunity, have been largely unexplored. Here, we probe the relationship between meditation and COVID-19 disease and directly test the impact of meditation on the induction of a blood environment that modulates viral infection. We found a significant inverse correlation between length of meditation practice and SARS-CoV-2 infection as well as accelerated resolution of symptomology of those infected. A meditation “dosing” effect was also observed. In cultured human lung cells, blood from experienced meditators induced factors that prevented entry of pseudotyped viruses for SARS-CoV-2 spike protein of both the wild-type Wuhan-1 virus and the Delta variant. We identified and validated SERPINA5, a serine protease inhibitor, as one possible protein factor in the blood of meditators that is necessary and sufficient for limiting pseudovirus entry into cells. In summary, we conclude that meditation can enhance resiliency to viral infection and may serve as a possible adjuvant therapy in the management of the COVID-19 pandemic.

Die COVID-19-Pandemie hat weltweit zu einer erheblichen Morbidität und Mortalität geführt. Die Bekämpfung der Pandemie stützte sich hauptsächlich auf SARS-CoV-2-Impfstoffe, während alternative Ansätze wie Meditation, die nachweislich die Immunität verbessern, weitgehend unerforscht blieben. Hier untersuchen wir den Zusammenhang zwischen Meditation und der COVID-19-Erkrankung und testen direkt die Auswirkungen von Meditation auf die Induktion einer Blutumgebung, die die Virusinfektion moduliert. Wir haben eine signifikante inverse Korrelation zwischen der Dauer der Meditationspraxis und der SARS-CoV-2-Infektion sowie eine beschleunigte Auflösung der Symptomatik bei Infizierten festgestellt. Es wurde auch ein Meditations-Dosierungseffekt beobachtet. In kultivierten menschlichen Lungenzellen induzierte das Blut erfahrener Meditierender Faktoren, die das Eindringen von pseudotypisierten Viren für das SARS-CoV-2-Spike-Protein sowohl des Wildtyp-Wuhan-1-Virus als auch der Delta-Variante verhinderten. Wir haben SERPINA5, einen Serinprotease-Inhibitor, als einen möglichen Proteinfaktor im Blut von Meditierenden identifiziert und validiert, der notwendig und ausreichend ist, um den Eintritt von Pseudoviren in Zellen zu begrenzen. Zusammenfassend kommen wir zu dem Schluss, dass Meditation die Widerstandsfähigkeit gegen Virusinfektionen erhöhen kann und als mögliche adjuvante Therapie bei der Bewältigung der COVID-19-Pandemie dienen kann.